KMID : 0854720060260030249
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Korean Journal of Asthma, Allergy and Clinical Immunology 2006 Volume.26 No. 3 p.249 ~ p.253
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A Case of Lidocaine Anaphylaxis
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Lee Sang-Min
Song Woo-Jung Yang Min-Suk Lee So-Hee Kwon Jae-Woo Kim Tae-Wan Kim Kyung-Mook Kim Hee-Kyu Park Chang-Han Park Heung-Woo Chang Yoon-Seok Kim Sun-Sin Kim Yoon-Keun Cho Sang-Heon Min Kyung-Up Kim You-Young
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Abstract
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A patient with a history of anaphylaxis after local administration of lidocaine was referred to screen a safe local anesthetic agent for dental procedures. We performed skin prick test with procaine, lidocaine, bupivacaine, mepivacaine, ropivacaine, and levobupivacaine. In accordance with the history of patient, lidocaine showed a positive result in skin prick test (wheal and flare reactions larger than those of histamine, a positive control) while other local anesthetics failed to produce positive reactions. Then, we performed the intradermal test with the above-mentioned anesthetics except lidocaine. As a result, procaine, mepivacaine, and bupiva caine showed positive results. Meanwhile, levobupivacaine and ropivacaine showed negative results in both the skin prick and the intradermal test and no systemic reactions after subcutaneous injection of testing dose (0.5%, 1:1 dilution, 3 mL) of levobupivacaine. Based on these results, we recommended levobupivacaine as a safe agent, and dental procedures were successfully done with it. This case clearly demonstrates that the cross reactivity between local anesthetics is unpredictable and should be confirmed before administration of a different anesthetic.
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KEYWORD
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Lidocaine, Anaphylaxis, Levobupivacaine, Cross-reactivity
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